Biologic Therapy for Nasal Polyps

Biologic therapies are injectable medications that target specific parts of the inflammatory pathway that drives nasal polyps and the chronic sinus inflammation associated with them. Rather than broadly suppressing the immune system, they block particular molecules involved in this type of inflammation.

For some people with chronic rhinosinusitis with nasal polyps, especially when polyps return despite topical treatment and surgery, or when there is associated asthma, biologics can reduce polyp size and improve symptoms such as congestion and sense of smell. They are not a fit for everyone and are chosen after evaluating the whole picture.

This page explains what biologics target, who may be considered, and how they compare with surgery, so you can have an informed discussion. It does not recommend a specific brand and does not make cost or coverage promises; treatment decisions and any insurance authorization are handled individually.

Because the same inflammation often affects the lower airway, many candidates also have asthma or aspirin-exacerbated respiratory disease. A history of recurrent polyps after sinus surgery is another factor that may favor considering a biologic. These conditions are taken into account when weighing options.

Biologic medications often require insurance authorization, and coverage and cost vary by plan. We can help with the documentation needed to request authorization, but we cannot guarantee coverage or specific costs. These details are reviewed individually as part of planning treatment.